Prostaglandin I2 signaling licenses Treg suppressive function and prevents pathogenic reprogramming
Abstract
Tregs restrain both the innate and adaptive immune systems to maintain homeostasis. Allergic airway inflammation, characterized by a Th2 response that results from a breakdown of tolerance to innocuous environmental antigens, is negatively regulated by Tregs. We previously reported that prostaglandin I2 (PGI2) promoted immune tolerance in models of allergic inflammation; however, the effect of PGI2 on Treg function was not investigated. Tregs...
Paper Details
Title
Prostaglandin I2 signaling licenses Treg suppressive function and prevents pathogenic reprogramming
Published Date
Apr 1, 2021
Volume
131
Issue
7
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