DNA damage response as a prognostic indicator in metastatic breast cancer via mutational analysis

High tumor heterogeneity contributes to breast cancer recurrence and metastasis. However, the lack of indicators to serve as precise and reliable means of predicting breast cancer prognosis has yet to be addressed. This study aims to reveal the prognostic relevance of mutations in metastatic breast cancer (MBC) by large-scale circulating tumor DNA (ctDNA) analysis in China.We performed ctDNA panel-captured sequencing of 958 blood samples from...