DNA methylation patterns identify subgroups of pancreatic neuroendocrine tumors with clinical association

Volume: 4, Issue: 1
Published: Feb 3, 2021
Abstract
Here we report the DNA methylation profile of 84 sporadic pancreatic neuroendocrine tumors (PanNETs) with associated clinical and genomic information. We identified three subgroups of PanNETs, termed T1, T2 and T3, with distinct patterns of methylation. The T1 subgroup was enriched for functional tumors and ATRX , DAXX and MEN1 wild-type genotypes. The T2 subgroup contained tumors with mutations in ATRX , DAXX and MEN1 and recurrent patterns of...
Paper Details
Title
DNA methylation patterns identify subgroups of pancreatic neuroendocrine tumors with clinical association
Published Date
Feb 3, 2021
Journal
Volume
4
Issue
1
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