Modeling the Human Body on Microfluidic Chips

Published on Aug 1, 2021in Trends in Biotechnology14.343
· DOI :10.1016/J.TIBTECH.2021.01.004
Sasan Jalili-Firoozinezhad14
Estimated H-index: 14
(MIT: Massachusetts Institute of Technology),
Cláudia C. Miranda7
Estimated H-index: 7
(IST: Instituto Superior Técnico),
Joaquim M. S. Cabral76
Estimated H-index: 76
(IST: Instituto Superior Técnico)
Animals often fail to faithfully mimic human diseases and drug toxicities, and most in vitro models are not complex enough to recapitulate human body function and pathophysiology. Organ-on-chip culture technology, however, offers a promising tool for the study of tissue development and homeostasis, which has brought us one step closer to performing human experimentation in vitro. To recapitulate the complex functionality of multiple organs at once, their respective on-chip models can be linked to create a functional human body-on-chip platform. Here, we highlight the advantages and translational potentials of body-on-chip platforms in disease modeling, therapeutic development, and personalized medicine. We provide the reader with current limitations of the body-on-chip approach and new ideas to address the pending issues moving forwards.
Using human-relevant, translational in vitro models is widely considered to reduce attrition during drug discovery and development. Despite this, the adoption of models based on microphysiological systems — organs-on-chips or organoids — by pharma companies is moderate at best, and realizing the full potential of these models will need greater collaboration between stakeholders. Using human-relevant, translational in vitro models is widely considered to reduce attrition during drug discovery and...
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