The preventive effect of total saponins from Panax japonicus on inflammation and insulin resistance in adipose tissue of mice induced by a high-fat diet

We aimed to investigate the effects of total saponins from Panax japonicus (TSPJ) on adipocyte inflammation and insulin resistance induced by a high-fat diet (HFD). Moreover, its underlying mechanism was further explored. In vivo, we found that TSPJ inhibited the activation of NF-κB and increase the transcription of p-AKT, leading to reduced inflammation and improved sensitivity of adipocytes to insulin. In vitro evaluation revealed that...