Therapeutic Potential of Resveratrol in COVID-19-Associated Hemostatic Disorders.

Published on Feb 6, 2021in Molecules3.267
· DOI :10.3390/MOLECULES26040856
Roberta Giordo13
Estimated H-index: 13
(College of Health Sciences, Bahrain),
Angelo Zinellu31
Estimated H-index: 31
(University of Sassari)
+ 1 AuthorsGianfranco Pintus32
Estimated H-index: 32
(College of Health Sciences, Bahrain)
Coagulation disorders, endotheliopathy and inflammation are the most common hallmarks in SARS-CoV-2 infection, largely determining COVID-19’s outcome and severity. Dysfunctions of endothelial cells and platelets are tightly linked in contributing to the systemic inflammatory response that appears to be both a cause and a consequence of COVID-19-associated coagulation disorders and thrombotic events. Indeed, elevated levels of circulating inflammatory cytokines are often associated with abnormal coagulation parameters in COVID-19 patients. Although treatments with low molecular weight heparin (LMWH) have shown beneficial effects in decreasing patient mortality with severe COVID-19, additional therapeutic strategies are urgently needed. Utilizing the anti-inflammatory and anti-thrombotic properties of natural compounds may provide alternative therapeutic approaches to prevent or reduce the risk factors associated with pre-existing conditions and comorbidities that can worsen COVID-19 patients’ outcomes. In this regard, resveratrol, a natural compound found in several plants and fruits such as grapes, blueberries and cranberries, may represent a promising coadjuvant for the prevention and treatment of COVID-19. By virtue of its anti-thrombotic and anti-inflammatory properties, resveratrol would be expected to lower COVID-19-associated mortality, which is well known to be increased by thrombosis and inflammation. This review analyzes and discusses resveratrol’s ability to modulate vascular hemostasis at different levels targeting both primary hemostasis (interfering with platelet activation and aggregation) and secondary hemostasis (modulating factors involved in coagulation cascade).
#1D. Jiménez (University of Alcalá)H-Index: 11
#1David Jiménez (University of Alcalá)H-Index: 18
Last. M. Monreal (Ciber)H-Index: 8
view all 10 authors...
Background Individual studies have reported widely variable rates for VTE and bleeding among hospitalized patients with coronavirus disease 2019 (COVID-19). Research Question What is the incidence of VTE and bleeding among hospitalized patients with COVID-19? Methods In this systematic review and meta-analysis, 15 standard sources and COVID-19-specific sources were searched between January 1, 2020, and July 31, 2020, with no restriction according to language. Incidence estimates were pooled by u...
28 CitationsSource
#1Roberta Giordo (College of Health Sciences, Bahrain)H-Index: 13
#2Panagiotis Paliogiannis (University of Sassari)H-Index: 19
Last. Gianfranco Pintus (University of Sassari)H-Index: 32
view all 4 authors...
SARS-CoV-2 is the agent responsible for the coronavirus disease (COVID-19), which has been declared a pandemic by the World Health Organization. The clinical evolution of COVID-19 ranges from asymptomatic infection to death. Older people and patients with underlying medical conditions, particularly diabetes, cardiovascular and chronic respiratory diseases are more susceptible to develop severe forms of COVID-19. Significant endothelial damage has been reported in COVID-19 and growing evidence su...
2 CitationsSource
#1Ana Laura Grazziotin (UFU: Federal University of Uberlandia)H-Index: 1
#2Newton M. Vidal (UFSM: Universidade Federal de Santa Maria)H-Index: 1
Last. Belchiolina Beatriz Fonseca (UFU: Federal University of Uberlandia)H-Index: 9
view all 10 authors...
Erysipelothrix sp. isolates obtained from a deadly outbreak in farmed turkeys were sequenced and compared to representatives of the genus. Phylogenetic trees-supported by digital DNA:DNA hybridization and Average Nucleotide Identity-revealed a novel monophyletic clade comprising isolates from pigs, turkeys, and fish, including isolates previously described as E. sp. Strain 2. Genes coding for the SpaC protein, typically found in E. sp. Strain 2, were detected in all isolates of the clade. Theref...
1 CitationsSource
#1Yu Zuo (UM: University of Michigan)H-Index: 13
#2Mark Warnock (UM: University of Michigan)H-Index: 14
Last. Daniel A. Lawrence (UM: University of Michigan)H-Index: 69
view all 10 authors...
Patients with coronavirus disease-19 (COVID-19) are at high risk for thrombotic arterial and venous occlusions. However, bleeding complications have also been observed in some patients. Understanding the balance between coagulation and fibrinolysis will help inform optimal approaches to thrombosis prophylaxis and potential utility of fibrinolytic-targeted therapies. 118 hospitalized COVID-19 patients and 30 healthy controls were included in the study. We measured plasma antigen levels of tissue-...
10 CitationsSource
#1Jaeseok KimH-Index: 18
#2Jun-Young LeeH-Index: 11
Last. Jae Il ShinH-Index: 32
view all 8 authors...
Severe coronavirus disease 2019 (COVID-19) is characterized by systemic hyper-inflammation, acute respiratory distress syndrome, and multiple organ failure. Cytokine storm refers to a set of clinical conditions caused by excessive immune reactions and has been recognized as a leading cause of severe COVID-19. While comparisons have been made between COVID-19 cytokine storm and other kinds of cytokine storm such as hemophagocytic lymphohistiocytosis and cytokine release syndrome, the pathogenesis...
10 CitationsSource
#2Marcin OżarowskiH-Index: 12
Last. Donald Wlodkowic (RMIT: RMIT University)H-Index: 16
view all 5 authors...
The global outbreak of a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) highlighted a requirement for two pronged clinical interventions such as development of effective vaccines and acute therapeutic options for medium-to-severe stages of "coronavirus disease 2019" (COVID-19). Effective vaccines, if successfully developed, have been emphasized to become the most effective strategy in the global fight against the COVID-19 pandemic. Basic research advances in biotechnology and...
9 CitationsSource
#1Geoffrey D. Wool (U of C: University of Chicago)H-Index: 12
#2Jonathan L. Miller (U of C: University of Chicago)H-Index: 5
Coronavirus disease 2019 (COVID-19) causes a spectrum of disease; some patients develop a severe proinflammatory state which can be associated with a unique coagulopathy and procoagulant endothelial phenotype. Initially, COVID-19 infection produces a prominent elevation of fibrinogen and D-dimer/fibrin(ogen) degradation products. This is associated with systemic hypercoagulability and frequent venous thromboembolic events. The degree of D-dimer elevation positively correlates with mortality in C...
29 CitationsSource
#1Zahra EslamifarH-Index: 1
#2Mahin BehzadifardH-Index: 1
Last. Saba Behzadifard (TMU: Tarbiat Modares University)H-Index: 1
view all 4 authors...
Among the pathways and mediators that may be dysregulated in COVID-19 infection, there are proinflammatory cytokines, lymphocyte apoptosis, and the coagulation cascade. Venous and arterial thromboembolisms also are frequent in COVID-19 patients with the increased risk of some life-threatening complications such as pulmonary embolism, myocardial infarction, and ischemic stroke. In this regard, overproduction of proinflammatory cytokines such as IL-6, IL-1β, and TNF-α induce cytokine storms, incre...
4 CitationsSource
#1Jessie Huang (BU: Boston University)H-Index: 15
#2Adam J. Hume (BU: Boston University)H-Index: 15
Last. Darrell N. Kotton (BU: Boston University)H-Index: 54
view all 22 authors...
A hallmark of severe COVID-19 pneumonia is SARS-CoV-2 infection of the facultative progenitors of lung alveoli, the alveolar epithelial type 2 cells (AT2s). However, inability to access these cells from patients, particularly at early stages of disease, limits an understanding of disease inception. Here, we present an in vitro human model that simulates the initial apical infection of alveolar epithelium with SARS-CoV-2 by using induced pluripotent stem cell-derived AT2s that have been adapted t...
46 CitationsSource
#1Giacomo Grasselli (University of Milan)H-Index: 32
#2Tommaso Tonetti (UNIBO: University of Bologna)H-Index: 19
Last. Carmen SeccaficoH-Index: 1
view all 38 authors...
Summary Background Patients with COVID-19 can develop acute respiratory distress syndrome (ARDS), which is associated with high mortality. The aim of this study was to examine the functional and morphological features of COVID-19-associated ARDS and to compare these with the characteristics of ARDS unrelated to COVID-19. Methods This prospective observational study was done at seven hospitals in Italy. We enrolled consecutive, mechanically ventilated patients with laboratory-confirmed COVID-19 a...
119 CitationsSource
Cited By1
#1Ali A. Samaha (Lebanese University)H-Index: 7
#2Hussein Mouawia (Lebanese University)H-Index: 2
Last. Houssam Raad (Lebanese University)
view all 16 authors...
Objective: This study was designed to determine the efficacy of ivermectin, an FDA-approved drug, in producing clinical benefits and decreasing the viral load of SARS-CoV-2 among asymptomatic subjects that tested positive for this virus in Lebanon. Methods: A randomized controlled trial was conducted in 100 asymptomatic Lebanese subjects that have tested positive for SARS-CoV2. Fifty patients received standard preventive treatment, mainly supplements, and the experimental group received a single...
Last. Tanja Cirkovic VelickovicH-Index: 23
view all 7 authors...
Resveratrol is a phytoalexin produced by many plants as a defense mechanism against stress-inducing conditions. The richest dietary sources of resveratrol are berries and grapes, their juices and wines. Good bioavailability of resveratrol is not reflected in its high biological activity in vivo because of resveratrol isomerization and its poor solubility in aqueous solutions. Proteins, cyclodextrins and nanomaterials have been explored as innovative delivery vehicles for resveratrol to overcome ...
#1David Dennison (Sultan Qaboos University)H-Index: 17
#2Murtadha Al Khabori (Sultan Qaboos University)H-Index: 3
Last. Ghalib Al Khadouri (Sultan Qaboos University)
view all 8 authors...
OBJECTIVES: Critical illness in COVID-19 is attributed to an exaggerated host immune response. Since neutrophils are the major component of innate immunity, we hypothesize that the quantum of activated neutrophils in the blood may predict adverse outcome. DESIGN: In a retrospective study of 300 Omani adult patients with confirmed COVID-19, we analyzed the impact of neutrophil activation (NEUT-RI), interleukin-6 (IL-6) and the established clinical risk factors of age, diabetes, obesity and hypert...