IgG-Engineered Protective Antigen for Cytosolic Delivery of Proteins into Cancer Cells
Abstract
Therapeutic immunotoxins composed of antibodies and bacterial toxins provide potent activity against malignant cells, but joining them with a defined covalent bond while maintaining the desired function is challenging. Here, we develop novel immunotoxins by dovetailing full-length immunoglobulin G (IgG) antibodies and nontoxic anthrax proteins, in which the C terminus of the IgG heavy chain is connected to the side chain of anthrax toxin...
Paper Details
Title
IgG-Engineered Protective Antigen for Cytosolic Delivery of Proteins into Cancer Cells
Published Date
Feb 4, 2021
Journal
Volume
7
Issue
2
Pages
365 - 378
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Notes
History