Heterogeneity of HSCs in a Mouse Model of NASH

Volume: 74, Issue: 2, Pages: 667 - 685
Published: Aug 1, 2021
Abstract
In clinical and experimental NASH, the origin of the scar-forming myofibroblast is the HSC. We used foz/foz mice on a Western diet to characterize in detail the phenotypic changes of HSCs in a NASH model.We examined the single-cell expression profiles (scRNA sequencing) of HSCs purified from the normal livers of foz/foz mice on a chow diet, in NASH with fibrosis of foz/foz mice on a Western diet, and in livers during regression of NASH after...
Paper Details
Title
Heterogeneity of HSCs in a Mouse Model of NASH
Published Date
Aug 1, 2021
Journal
Volume
74
Issue
2
Pages
667 - 685
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