Synthesis and biological evaluation of novel withangulatin A derivatives as potential anticancer agents

Volume: 108, Pages: 104690 - 104690
Published: Mar 1, 2021
Abstract
Novel withangulatin A (WA) derivatives were synthesized and evaluated for antiproliferative activity against four human cancer cell lines (U2OS, MDA-MB-231, HepG2, and A549). Among these derivatives, 10 exhibited the most potent antiproliferative activity, with an IC50 value of 74.0 nM against the human breast cancer cell line MDA-MB-231 and potency that was 70-fold that of WA (IC50 = 5.22 µM). Moreover, 10 caused G2-phase cell cycle arrest in a...
Paper Details
Title
Synthesis and biological evaluation of novel withangulatin A derivatives as potential anticancer agents
Published Date
Mar 1, 2021
Volume
108
Pages
104690 - 104690
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