Cyfip1 Regulates SynGAP1 at Hippocampal Synapses

Volume: 12
Published: Feb 5, 2021
Abstract
In humans, copy number variations in CYFIP1 appear to have sweeping physiological and structural consequences in the brain, either producing or altering the severity of intellectual disability, autism, and schizophrenia. Independently, SynGAP1 haploinsufficiency produces intellectual disability and, frequently, autism. Cyfip1 inhibits protein translation and promotes actin polymerization, and SynGAP1 is a synaptically localized Ras/Rap GAP....
Paper Details
Title
Cyfip1 Regulates SynGAP1 at Hippocampal Synapses
Published Date
Feb 5, 2021
Volume
12
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