Treat-and-extend therapy with aflibercept for diabetic macular edema: a prospective clinical trial

To investigate the efficacy and safety of a treat-and-extend (T&E) regimen using aflibercept (Eylea) for diabetic macular edema (DME). Prospective, open-label, multicenter, single-arm, nonblinded clinical study. Forty eyes of 40 patients with DME received a T&E regimen of intravitreal aflibercept injection (IAI) with the longest treatment interval set to 16 weeks and adjunct focal/grid laser for 1 year. An intent-to-treat analysis was performed...