Virology

Antibody

Ecology

Immunoglobulin G

Immune system

Microbiology

Humoral immunity

Biology

Mycobiota

Immunity

Immunology

Cell

Doron et al. present evidence that commensal fungi in the human gut shape antibody responses in the blood to protect the host from systemic lethal fungal infections. The innate immunity regulator CARD9 and CARD9+CX3CR1+ macrophages play an important role in antifungal IgG production, which is decreased in CARD9-deficient patients.

Human gut mycobiota tune immunity via CARD9-dependent induction of anti-fungal IgG antibodies