Strategies to Target ADAM17 in Disease: From Its Discovery to the iRhom Revolution
Abstract
For decades, disintegrin and metalloproteinase 17 (ADAM17) has been the object of deep investigation. Since its discovery as the tumor necrosis factor convertase, it has been considered a major drug target, especially in the context of inflammatory diseases and cancer. Nevertheless, the development of drugs targeting ADAM17 has been harder than expected. This has generally been due to its multifunctionality, with over 80 different transmembrane...
Paper Details
Title
Strategies to Target ADAM17 in Disease: From Its Discovery to the iRhom Revolution
Published Date
Feb 10, 2021
Journal
Volume
26
Issue
4
Pages
944 - 944
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