Multi‐institutional dose‐segmented dosiomic analysis for predicting radiation pneumonitis after lung stereotactic body radiation therapy

Purpose To predict radiation pneumonitis (RP) grade 2 or worse after lung stereotactic body radiation therapy (SBRT) using dose‐based radiomic (dosiomic) features. Methods This multi‐institutional study included 247 early‐stage nonsmall cell lung cancer patients who underwent SBRT with a prescribed dose of 48–70 Gy at an isocenter between June 2009 and March 2016. Ten dose–volume indices (DVIs) were used, including the mean lung dose, internal...