TRIM28 maintains genome imprints and regulates development of porcine SCNT embryos
Abstract
Pre-implantation embryos undergo genome-wide DNA demethylation, however certain regions, like imprinted loci remain methylated. Further, the mechanisms ensuring demethylation resistance by TRIM28 in epigenetic reprogramming remain poorly understood. Here, TRIM28 was knocked down in oocytes, and its effects on porcine somatic cell nuclear transfer (SCNT) embryo development was examined. Our results showed that SCNT embryos constructed from TRIM28...
Paper Details
Title
TRIM28 maintains genome imprints and regulates development of porcine SCNT embryos
Published Date
Apr 1, 2021
Journal
Volume
161
Issue
4
Pages
411 - 424
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