Differential Contribution Of TNFSF14/LIGHT-Receptor Mediated Pathways To Inflammatory Fibroblast Phenotypes In Eosinophilic Esophagitis

Fibroblasts (FBL) mediate tissue remodeling in eosinophilic esophagitis (EoE), a chronic allergen driven inflammatory pathology. We recently defined a putative role of the cytokine TNFSF14/LIGHT as a promoter of an inflammatory esophageal FBL subtype. LIGHT can signal through two receptors, herpes virus entry mediator (HVEM) and lymphotoxin-beta receptor (LTßR). We investigated the relative contributions of each receptor to LIGHT-mediated...