Helical Antimicrobial Peptide Foldamers Containing Non‐proteinogenic Amino Acids
Abstract
Antimicrobial peptides (AMPs) are potential novel therapeutic drugs against microbial infections. Most AMPs function by disrupting microbial membranes because of their amphipathic properties and ordered secondary structures. In this minireview, we describe recent efforts to develop helical AMP foldamers containing non-proteinogenic amino acids, such as α,α-disubstituted α-amino acids, β-amino acids, γ-amino acids, side-chain stapling and N-alkyl...
Paper Details
Title
Helical Antimicrobial Peptide Foldamers Containing Non‐proteinogenic Amino Acids
Published Date
Feb 10, 2021
Journal
Volume
16
Issue
8
Pages
1226 - 1233
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