Mutant p53 Gain-of-Function: Role in Cancer Development, Progression, and Therapeutic Approaches
Abstract
Frequent p53 mutations (mutp53) not only abolish tumor suppressor capacities but confer various gain-of-function (GOF) activities that impacts molecules and pathways now regarded as central for tumor development and progression. Although the complete impact of GOF is still far from being fully understood, the effects on proliferation, migration, metabolic reprogramming, and immune evasion, among others, certainly constitute major driving forces...
Paper Details
Title
Mutant p53 Gain-of-Function: Role in Cancer Development, Progression, and Therapeutic Approaches
Published Date
Feb 11, 2021
Volume
8
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