Targeting novel human transient receptor potential ankyrin 1 splice variation with splice-switching antisense oligonucleotides
Abstract
In Brief Activation of transient receptor potential ankyrin 1 (TRPA1) channels by both environmental irritants and endogenous inflammatory mediators leads to excitation of the nerve endings, resulting in acute sensation of pain, itch, or chronic neurogenic inflammation. As such, TRPA1 channels are actively pursued as therapeutic targets for various pathological nociception and pain disorders. We uncovered that exon 27 of human TRPA1 (hTRPA1)...
Paper Details
Title
Targeting novel human transient receptor potential ankyrin 1 splice variation with splice-switching antisense oligonucleotides
Published Date
Jan 26, 2021
Journal
Volume
162
Issue
7
Pages
2097 - 2109
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