Dysglycemia and Dyslipidemia Models in Nonhuman Primates: Part V. Diabetic Nephropathy and Effects of Angiotensin and#8545; Receptor AntagonistLosartan

Long-term hyperglycemia can impair renal microvessels and lead to diabetic nephropathy (DN). Early treatment can delay or prevent its progression. Efficacy of monoclonal antibody (mAb) therapies for human diseases can often be tested only in nonhuman primates (NHPs) but no other species due to lack of human mAb cross-reactivity. To test if DN in NHPs is similar to the human disease, this study analyzed the blood and urine biochemistry data from...