Variants in PCSK7, PNPLA3 and TM6SF2 are risk factors for the development of cirrhosis in hereditary haemochromatosis.

Volume: 53, Issue: 7, Pages: 830 - 843
Published: Apr 1, 2021
Abstract
Cirrhosis develops in <10% of individuals homozygous for the C282Y variant in the homeostatic iron regulator (HFE) gene. Carriage of PCSK7:rs236918 is associated with an increased risk of cirrhosis in this population.To determine if genetic variants significantly associated with the risk of alcohol- and NAFLD-related cirrhosis also modulate the cirrhosis risk in C282Y homozygotes.Variants in PCSK7, PNPLA3, TM6SF2, MBOAT7 and HSD17B13 were...
Paper Details
Title
Variants in PCSK7, PNPLA3 and TM6SF2 are risk factors for the development of cirrhosis in hereditary haemochromatosis.
Published Date
Apr 1, 2021
Journal
Volume
53
Issue
7
Pages
830 - 843
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