Thrombotic Thrombocytopenic Purpura: Pathophysiology, Diagnosis, and Management
Abstract
Thrombotic thrombocytopenic purpura (TTP) is a rare thrombotic microangiopathy characterized by microangiopathic hemolytic anemia, severe thrombocytopenia, and ischemic end organ injury due to microvascular platelet-rich thrombi. TTP results from a severe deficiency of the specific von Willebrand factor (VWF)-cleaving protease, ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats, member 13). ADAMTS13 deficiency is most...
Paper Details
Title
Thrombotic Thrombocytopenic Purpura: Pathophysiology, Diagnosis, and Management
Published Date
Feb 2, 2021
Journal
Volume
10
Issue
3
Pages
536 - 536
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