Baicalein inhibits heparin-induced Tau aggregation by initializing non-toxic Tau oligomer formation
Abstract
Amyloid aggregate deposition is the key feature of Alzheimer's disease. The proteinaceous aggregates found in the afflicted brain are the intra-neuronal neurofibrillary tangles formed by the microtubule-associated protein Tau and extracellular deposits, senile plaques, of amyloid beta (Aβ) peptide proteolytically derived from the amyloid precursor protein. Accumulation of these aggregates has manifestations in the later stages of the disease,...
Paper Details
Title
Baicalein inhibits heparin-induced Tau aggregation by initializing non-toxic Tau oligomer formation
Published Date
Feb 12, 2021
Volume
19
Issue
1
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