Mapping Disease Course Across the Mood Disorder Spectrum Through a Research Domain Criteria Framework

The National Institute of Mental Health Research Domain Criteria (RDoC) initiative aims to establish a neurobiologically valid framework for classifying mental illness. Here, we examined whether the RDoC construct of reward learning and three aspects of its underlying neurocircuitry predicted symptom trajectories in individuals with mood pathology.Aligning with the RDoC approach, we recruited individuals (n = 80 with mood disorders [58 unipolar...