Post-transcriptional regulation by the exosome complex is required for cell survival and forebrain development via repression of P53 signaling
Abstract
Fine-tuned gene expression is crucial for neurodevelopment. The gene expression program is tightly controlled at different levels, including RNA decay. N6-methyladenosine (m6A) methylation-mediated degradation of RNA is essential for brain development. However, m6A methylation impacts not only RNA stability, but also other RNA metabolism processes. How RNA decay contributes to brain development is largely unknown. Here, we show that Exosc10, a...
Paper Details
Title
Post-transcriptional regulation by the exosome complex is required for cell survival and forebrain development via repression of P53 signaling
Published Date
Feb 1, 2021
Journal
Volume
148
Issue
3
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