Pancreatic beta cell autophagy is impaired in type 1 diabetes
Abstract
Pancreatic beta cells are subjected to exogenous damaging factors such as proinflammatory cytokines or excess glucose that can cause accumulation of damage-inducing reactive oxygen species during the pathogenesis of diabetes. We and others have shown that beta cell autophagy can reduce reactive oxygen species to protect against apoptosis. While impaired islet autophagy has been demonstrated in human type 2 diabetes, it is unknown if islet...
Paper Details
Title
Pancreatic beta cell autophagy is impaired in type 1 diabetes
Published Date
Jan 30, 2021
Journal
Volume
64
Issue
4
Pages
865 - 877
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