AGO-accessible anticancer siRNAs designed with synergistic miRNA-like activity
Abstract
Small interfering RNAs (siRNAs) therapeutically induce RNA interference (RNAi) of disease-causing genes, but they also silence hundreds of seed-matched off-targets as behaving similar to microRNAs (miRNAs). miRNAs control the pathophysiology of tumors, wherein their accessible binding sites can be sequenced by Argonaute crosslinking immunoprecipitation (AGO CLIP). Herein, based on AGO CLIP, we develop potent anticancer siRNAs utilizing...
Paper Details
Title
AGO-accessible anticancer siRNAs designed with synergistic miRNA-like activity
Published Date
Mar 1, 2021
Volume
23
Pages
1172 - 1190
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