Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction
Abstract
Endothelial cells play a critical role in the adaptation of tissues to injury. Tissue ischemia induced by infarction leads to profound changes in endothelial cell functions and can induce transition to a mesenchymal state. Here we explore the kinetics and individual cellular responses of endothelial cells after myocardial infarction by using single cell RNA sequencing. This study demonstrates a time dependent switch in endothelial cell...
Paper Details
Title
Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction
Published Date
Jan 29, 2021
Journal
Volume
12
Issue
1
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