Cdk1 phosphorylation negatively regulates the activity of Net1 towards RhoA during mitosis
Abstract
The Neuroepithelial transforming gene 1 (Net1) is a RhoA subfamily guanine nucleotide exchange factor that is overexpressed in a number of cancers and contributes to cancer cell motility and proliferation. Net1 also plays a Rho GTPase independent role in mitotic progression, where it promotes centrosomal activation of Aurora A and Pak2, and aids in chromosome alignment during prometaphase. To understand regulatory mechanisms controlling the...
Paper Details
Title
Cdk1 phosphorylation negatively regulates the activity of Net1 towards RhoA during mitosis
Published Date
Apr 1, 2021
Journal
Volume
80
Pages
109926 - 109926
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