An improved assay for detection of theranostic gene translocations and MET exon 14 skipping in thoracic oncology
Abstract
Theranostic translocations may be difficult to detect by routine techniques, especially when specimens are exiguous. We recently demonstrated in a series of translocated lung adenocarcinomas that LD-RT-PCR (ligation-dependent reverse transcription polymerase chain reaction) assay could identify ALK, ROS1 and RET rearrangements with 64% sensitivity and 100% specificity. Here, we report an upgraded version of this assay used in a routine...
Paper Details
Title
An improved assay for detection of theranostic gene translocations and MET exon 14 skipping in thoracic oncology
Published Date
May 1, 2021
Journal
Volume
101
Issue
5
Pages
648 - 660
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