Angiotensin-converting enzyme (ACE) insertion/deletion gene polymorphism across ethnicity: a narrative review of performance gene

Angiotensin-converting enzyme (ACE) gene has been reported to be one of the candidate genes for endurance performance. The ACE gene insertion/deletion (I/D) polymorphism (rs4646994) is responsible for the variation in the ACE plasma level. The insertion (I allele) of ACE I/D gene polymorphism decreases the level of ACE plasma, thus reducing skeletal muscle vasoconstriction. Skeletal muscle vasoconstriction increases oxygenated blood supply to...