Targeting TRIM Proteins: A Quest towards Drugging an Emerging Protein Class
Abstract
The ubiquitylation machinery regulates several fundamental biological processes from protein homeostasis to a wide variety of cellular signaling pathways. As a consequence, its dysregulation is linked to diseases including cancer, neurodegeneration, and autoimmunity. With this review, we aim to highlight the therapeutic potential of targeting E3 ligases, with a special focus on an emerging class of RING ligases, named tri‐partite motif (TRIM)...
Paper Details
Title
Targeting TRIM Proteins: A Quest towards Drugging an Emerging Protein Class
Published Date
Mar 18, 2021
Journal
Volume
22
Issue
12
Pages
2011 - 2031
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Notes
History