Autonomic dyshomeostasis in patients with diabetes mellitus during COVID-19.

Published on Jan 15, 2021in Nature Reviews Endocrinology28.8
· DOI :10.1038/S41574-021-00466-5
Virginia Boccardi1
Estimated H-index: 1
#1Dominik WolffH-Index: 2
#2Sarah NeeH-Index: 1
Last. Michael MarschollekH-Index: 27
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Covid-19 is a global threat that pushes health care to its limits. Since there is neither a vaccine nor a drug for Covid-19, people with an increased risk for severe and fatal courses of disease particularly need protection. Furthermore, factors increasing these risks are of interest in the search of potential treatments. A systematic literature review on the risk factors of severe and fatal Covid-19 courses is presented. The review is carried out on PubMed and a publicly available preprint data...
35 CitationsSource
#1Soo Lim (Seoul National University Bundang Hospital)H-Index: 64
#2Jae Hyun Bae (KU: Korea University)H-Index: 15
Last. Michael A. Nauck (RUB: Ruhr University Bochum)H-Index: 108
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Initial studies found increased severity of coronavirus disease 2019 (COVID-19), caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in patients with diabetes mellitus. Furthermore, COVID-19 might also predispose infected individuals to hyperglycaemia. Interacting with other risk factors, hyperglycaemia might modulate immune and inflammatory responses, thus predisposing patients to severe COVID-19 and possible lethal outcomes. Angiotensin-converting enzyme 2 (A...
56 CitationsSource
#1Georgios Theocharidis (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 6
#2Aristidis Veves (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 77
Abstract Lower extremity ulcerations represent a major complication in diabetes mellitus and involve multiple physiological factors that lead to impairment of wound healing. Neuropeptides are neuromodulators implicated in various processes including diabetic wound healing. Diabetes causes autonomic and small sensory nerve fibers neuropathy as well as inflammatory dysregulation, which manifest with decreased neuropeptide expression and a disproportion in pro- and anti- inflammatory cytokine respo...
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#1Michael J. Kenney (KSU: Kansas State University)H-Index: 22
#2Chanran K. Ganta (KSU: Kansas State University)H-Index: 8
The present review assesses the current state of literature defining integrative autonomic-immune physiological processing, focusing on studies that have employed electrophysiological, pharmacological, molecular biological and central nervous system experimental approaches. Central autonomic neural networks are informed of peripheral immune status via numerous communicating pathways, including neural and non-neural. Cytokines and other immune factors affect the level of activity and responsivity...
129 CitationsSource
The immune, endocrine and nervous systems interact with each other by means of cytokines, hormones and neurotransmitters. Interaction is dependent on specific receptors and respective signaling pathways in target cells. During aging, changes occur on many levels of these global systems which depend on oxidative damage, non-enzymatic glycosylation, mitochondrial mutations, defects in cell cycle control, mitotic dysregulation, genome instability, telomere shortening and other chromosomal pathologi...
152 CitationsSource
Cited By1
#1Soo Lim (Seoul National University Bundang Hospital)H-Index: 64
#2Jae Hyun Bae (KU: Korea University)H-Index: 15
Last. Michael A. Nauck (RUB: Ruhr University Bochum)H-Index: 108
view all 4 authors...