Conserved regulatory logic at accessible and inaccessible chromatin during the acute inflammatory response in mammals

Volume: 12, Issue: 1
Published: Jan 25, 2021
Abstract
The regulatory elements controlling gene expression during acute inflammation are not fully elucidated. Here we report the identification of a set of NF-κB-bound elements and common chromatin landscapes underlying the acute inflammatory response across cell-types and mammalian species. Using primary vascular endothelial cells (human/mouse/bovine) treated with the pro−inflammatory cytokine, Tumor Necrosis Factor-α, we identify extensive (~30%)...
Paper Details
Title
Conserved regulatory logic at accessible and inaccessible chromatin during the acute inflammatory response in mammals
Published Date
Jan 25, 2021
Volume
12
Issue
1
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