Conserved regulatory logic at accessible and inaccessible chromatin during the acute inflammatory response in mammals
Abstract
The regulatory elements controlling gene expression during acute inflammation are not fully elucidated. Here we report the identification of a set of NF-κB-bound elements and common chromatin landscapes underlying the acute inflammatory response across cell-types and mammalian species. Using primary vascular endothelial cells (human/mouse/bovine) treated with the pro−inflammatory cytokine, Tumor Necrosis Factor-α, we identify extensive (~30%)...
Paper Details
Title
Conserved regulatory logic at accessible and inaccessible chromatin during the acute inflammatory response in mammals
Published Date
Jan 25, 2021
Journal
Volume
12
Issue
1
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