STIM-Orai1 signaling regulates fluidity of cytoplasm during membrane blebbing
Abstract
The cytoplasm in mammalian cells is considered homogeneous. In this study, we report that the cytoplasmic fluidity is regulated in the blebbing cells; the cytoplasm of rapidly expanding membrane blebs is more disordered than the cytoplasm of retracting blebs. The increase of cytoplasmic fluidity in the expanding bleb is caused by a sharp rise in the calcium concentration. The STIM-Orai1 pathway regulates this rapid and restricted increase of...
Paper Details
Title
STIM-Orai1 signaling regulates fluidity of cytoplasm during membrane blebbing
Published Date
Jan 20, 2021
Journal
Volume
12
Issue
1
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