The Role of the Microenvironment and Immune System in Regulating Stem Cell Fate in Cancer

Resistance to therapy and metastatic progression are two critical drivers of poor clinical outcome across cancers.Aggressive subpopulations of cells that are enriched for stem cell signals, sometimes referred to as ‘cancer stem cells,’ are thought to be crucial drivers of these malignant features of disease.Although a great deal of work in the field has focused on targeting the intrinsic dependencies of these aggressive cells, recent studies...