Vasodilation

Internal medicine

Organic chemistry

Blood pressure

Biology

Pannexin

Endocrinology

Hemodynamics

Gap junction

Chemistry

Haemodynamic response

Heart rate

Extracellular

Connexin

Cell biology

Oxygen

Medicine

Hypoxia (environmental)

Intracellular

AJP Heart and Circulatory Physiology

Pannexin 1 (Panx1) channels export ATP and may contribute to increased concentration of the vasodilator ATP in plasma during hypoxia in vivo. We hypothesized that Panx1 channels and associated ATP export contribute to hypoxic vasodilation, a mechanism that facilitates the matching of oxygen delivery to metabolic demand of tissue. Male and female mice devoid of Panx1 (

Pannexin 1 channels control the hemodynamic response to hypoxia by regulating O<sub>2</sub>-sensitive extracellular ATP in blood

Pannexin 1 channels control the hemodynamic response to hypoxia by regulating O2-sensitive extracellular ATP in blood

Pannexin 1 channels control the hemodynamic response to hypoxia by regulating O₂-sensitive extracellular ATP in blood