Metabolomic Profiles and Heart Failure Risk in Black Adults: Insights From the Jackson Heart Study

Heart failure (HF) is a heterogeneous disease characterized by significant metabolic disturbances; however, the breadth of metabolic dysfunction before the onset of overt disease is not well understood. The purpose of this study was to determine the association of circulating metabolites with incident HF to uncover novel metabolic pathways to disease.We performed targeted plasma metabolomic profiling in a deeply phenotyped group of Black adults...