Comparison of multi echo T2 relaxation and steady state approaches for myelin imaging in the central nervous system

The traditional approach for measuring myelin-associated water with quantitative magnetic resonance imaging (MRI) uses multi-echo T 2 relaxation data to calculate the myelin water fraction (MWF). A fundamentally different approach, abbreviated “mcDESPOT”, uses a more efficient steady-state acquisition to generate an equivalent metric (f M ). Although previous studies have demonstrated inherent instability and bias in the complex mcDESPOT...