Differential Network Analysis Reveals Regulatory Patterns in Neural Stem Cell Fate Decision

Deciphering regulatory patterns of neural stem cell (NSC) differentiation with multiple stages is essential to understand NSC differentiation mechanisms. Recent single-cell transcriptome datasets became available at individual differentiation. However, a systematic and integrative analysis of multiple datasets at multiple temporal stages of NSC differentiation is lacking. In this study, we propose a new method integrating prior information to...