Structural Characterization and Health Effects of Polysaccharides from Momordica charantia on Diabetes Mellitus

Published on Jan 1, 2021
· DOI :10.1007/978-981-15-8791-7_7
Xuan Liu1
Estimated H-index: 1
Shen Mingyue + 1 AuthorsJianhua Xie
#1Rong Huang (NCU: Nanchang University)H-Index: 2
#2Jianhua Xie (NCU: Nanchang University)H-Index: 35
Last. Mingyue Shen (NCU: Nanchang University)H-Index: 29
view all 4 authors...
Abstract Yam (Dioscorea spp.), known as an edible and medicinal tuber crop in China, has been used historically for the treatment of diabetes, diarrhea, asthma, and other ailments in traditional Chinese medicine. Moreover, it has been consumed as starchy food for thousands of years in China. Modern phytochemistry and pharmacological experiments have been proved that non-starch polysaccharide is one of the main bioactive substances of yam. Many studies have been focused on the isolation and ident...
12 CitationsSource
#1Mingyi Chen (SYSU: Sun Yat-sen University)H-Index: 6
#2Dan Xiao (SYSU: Sun Yat-sen University)H-Index: 5
Last. Zhiyong Xie (SYSU: Sun Yat-sen University)H-Index: 13
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Abstract Ganoderma lucidum polysaccharides (GLP), a kind of medicinal mushrooms, were widely used in southeastern countries with putative anti-diabetic effects. In order to unravel the underlying mechanism of its anti-diabetic effect, this study examines the effects of GLP on gut microbiota composition and functions in type 2 diabetes mellitus (T2DM) status. In this study, the effects of GLP on the gut microbiota and fecal metabolites in high-fat diet and streptozotocin-induced T2DM rats were ex...
29 CitationsSource
#1Yi Ru (Shenyang Agricultural University)H-Index: 1
#2Kexin Liu (Shenyang Agricultural University)H-Index: 1
Last. Hongman Chen (Shenyang Agricultural University)H-Index: 3
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Abstract In order to obtain the effective antidiabetic polysaccharide derivative, a selenylated polysaccharide (Se-MCPIIa-1), with an average molecular weight (MW) of 4.0038 × 104 Da, was synthesized by reduction of sodium selenite with ascorbic acid in the presence of Momordica polysaccharides (MCPIIa). The selenium (Se) content of Se-MCPIIa-1 was up to 445.0 μg/g, and its average diameter of monodisperse spherical particle size was around 63.78 nm. The morphology and physicochemical properties...
8 CitationsSource
#1Guangjie Wu (Jiangxi Science and Technology Normal University)H-Index: 3
#2Zhouya Bai (NCU: Nanchang University)H-Index: 2
Last. Shaoping Nie (NCU: Nanchang University)H-Index: 65
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Abstract The prevalence of type 2 diabetes mellitus (T2DM) is increasing year by year worldwide, which threatens human health severely. This study aimed to investigate the antidiabetic effects and the potential mechanism of polysaccharide from azuki bean (ABP) in high fat diet and STZ-induced type 2 diabetic rats. Results showed that oral administration of ABP could significantly reduce weight loss and fasting blood glucose (FBG) levels and concentration of serum triglyceride (TG) compared with ...
14 CitationsSource
#1Rui-Bo Jia (SCUT: South China University of Technology)H-Index: 3
#2Zhao-Rong Li (SCUT: South China University of Technology)H-Index: 3
Last. Mouming Zhao (SCUT: South China University of Technology)H-Index: 50
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Abstract Two polysaccharide fractions (SFPs, designated as respectively SFP-1 and SFP-2) were acquired from Sargassum fusiforme by ultrasound-assisted enzymatic extraction, and their physicochemical properties and hypoglycemic and hypolipidemic effects were investigated. Structural analysis indicated that SFPs were obvious different in the zeta potential, molecular weight distribution, characteristic organic group, microstructure and the contents of total sugar, uronic acid, sulfate and moisture...
16 CitationsSource
#1Xianlong Zhang (Shaanxi University of Science and Technology)H-Index: 6
#2Guoliang Li (Shaanxi University of Science and Technology)H-Index: 34
Last. Yongning Wu (CFS: Center for Food Safety)H-Index: 67
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The high incidence of diabetes mellitus has caused widespread concern around the world, which has quickly become one of the most prevalent and costly chronic diseases. Alpha-glucosidase has been considered as the main target enzyme in the prevention and treatment of type 2 diabetes, and the inhibition of alpha-glucosidase activity can control postprandial blood glucose levels of diabetics and keep blood glucose levels normal. However, most of the current antidiabetic drugs in the clinic have man...
17 CitationsSource
#1Emanuel L. Peter (NIMR: National Institute for Medical Research)H-Index: 6
#2Andrew G. Mtewa (Mbarara University of Science and Technology)H-Index: 3
Last. Crispin Duncan Sesaazi (Mbarara University of Science and Technology)H-Index: 2
view all 5 authors...
BACKGROUND: Studies on several preclinical models of type 2 diabetes mellitus have been conducted to establish the hypoglycemic activity of Momordica charantia L. Concerned with appropriateness of these models, we designed a systematic review to establish the efficacy and safety of M. charantia L. in preclinical models of type 2 diabetes mellitus. METHODS: Review authors will search without language restriction in MEDLINE/PubMed, Web of Science, Embase, Scopus, and CINAHL databases through April...
6 CitationsSource
#1Wu-Dan Cai (Jiangsu University)H-Index: 9
#2Zhi-Chao Ding (Jiangsu University)H-Index: 7
Last. Jing-Kun Yan (Jiangsu University)H-Index: 24
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Abstract In this study, the hypoglycemic effect and possible mechanism of a polysaccharide, HEP-C, isolated from the fruit body of Hericium erinaceus were evaluated in streptozotoxin (STZ)-induced diabetic rats. Compared with the untreated STZ-induced diabetic rats, the supplements with HEP-C (150 and 300 mg/kg body weight [BW]) could significantly and dose-dependently relieve BW loss and organ injures, reduce fasting blood glucose, enhance glucose tolerance, alleviate hepatic function and serum...
7 CitationsSource
#1Fuqiang Zhao (Haida: Hainan University)H-Index: 2
#2Qibing Liu (HMU: Hainan Medical University)H-Index: 2
Last. Chuan Li (Haida: Hainan University)H-Index: 5
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Abstract Diabetes mellitus has become a worldwide concern in recent years. In this study, the effect of Holothuria leucospilota polysaccharide (HLP) on type 2 diabetes mellitus (T2DM) was investigated in Goto-Kakizaki (GK) rats. The results showed that HLP significantly improved glucose intolerance and regulated blood lipid and hormone levels (p
17 CitationsSource
#1U.F. Magaji (Istanbul University)H-Index: 1
#1U.F. Magaji (Istanbul University)H-Index: 3
Last. Refiye Yanardag (Istanbul University)H-Index: 29
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Abstract Moringa oleifera is a source of food, shelter and traditional medicine for many people in developing countries. It is an exceptional source of vitamins, minerals, amino acids, lipids, carotenoids, flavonoids, sterols and phenolics. Owing to its diverse nutritional and phytochemical composition, it is widely consumed and used in therapeutics. In this study, the aqueous, methanol, hexane and ethyl acetate extracts of M. oleifera seeds, leaves and roots were assessed for in vitro α-amylase...
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