Reconstructing tumor history in breast cancer: signatures of mutational processes and response to neoadjuvant chemotherapy⋆

Volume: 32, Issue: 4, Pages: 500 - 511
Published: Apr 1, 2021
Abstract
•The development of tumors is driven by endogenous and exogenous mutational processes acting over long periods of time.•These processes generate a specific landscape of mutational signatures for each individual tumor.•Mutational signatures of 405 tumor samples from a neoadjuvant clinical trial were correlated with therapy response and disease-free survival.•In particular, HRD-, APOBEC-, and tobacco-related signatures were associated with therapy...
Paper Details
Title
Reconstructing tumor history in breast cancer: signatures of mutational processes and response to neoadjuvant chemotherapy⋆
Published Date
Apr 1, 2021
Volume
32
Issue
4
Pages
500 - 511
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