FAM134B-RHD Protein Clustering Drives Spontaneous Budding of Asymmetric Membranes

Published: Jan 4, 2021
Abstract
null Living cells constantly remodel the shape of their lipid membranes. In the endo-plasmic reticulum (ER), the reticulon homology domain (RHD) of the reticulophagy regulator 1 (RETR1/FAM134B) forms dense autophagic puncta that are associated with membrane removal by ER-phagy. In molecular dynamics (MD) simulations, we find that FAM134B-RHD spontaneously forms clusters, driven in part by curvature-mediated attraction. At a critical size, the...
Paper Details
Title
FAM134B-RHD Protein Clustering Drives Spontaneous Budding of Asymmetric Membranes
Published Date
Jan 4, 2021
Journal
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