YAP/TAZ inhibition reduces metastatic potential of Ewing sarcoma cells

Lisa Bierbaumer; Anna M. Katschnig; Branka Radic-Sarikas; Maximilian Kauer; Jeffrey A. Petro; Sandra Högler; Elisabeth Gurnhofer; Gloria Pedot; Beat W. Schäfer; Raphaela Schwentner; Aykut Üren; Heinrich Kovar

doi:https://doi.org/10.1038/s41389-020-00294-8

doi.org/10.1038/s41389-020-00294-8

YAP/TAZ inhibition reduces metastatic potential of Ewing sarcoma cells

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..., Heinrich Kovar

44

Oncogenesis6.20

Volume: 10, Issue: 1

Published: Jan 8, 2021

Abstract

Ewing sarcoma (EwS) is a highly metastatic bone cancer characterized by the ETS fusion oncoprotein EWS-FLI1. EwS cells are phenotypically highly plastic and switch between functionally distinct cell states dependent on EWS-FLI1 fluctuations. Whereas EWS-FLI1high cells proliferate, EWS-FLI1low cells are migratory and invasive. Recently, we reported activation of MRTFB and TEAD, effectors of RhoA and Hippo signalling, upon low EWS-FLI1,...

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Paper Details

Title

YAP/TAZ inhibition reduces metastatic potential of Ewing sarcoma cells

DOI

doi.org/10.1038/s41389-020-00294-8

Published Date

Jan 8, 2021

Journal

Oncogenesis

Volume

10

Issue

1

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