Associations between depression and cardiometabolic health: A 27-year longitudinal study.

Published on Jan 12, 2021in Psychological Medicine5.813
· DOI :10.1017/S003329172000505X
Hillary L Ditmars1
Estimated H-index: 1
(BU: Boston University),
Mark W. Logue33
Estimated H-index: 33
(BU: Boston University)
+ 24 AuthorsMichael J. Lyons85
Estimated H-index: 85
(BU: Boston University)
Background Clarifying the relationship between depression symptoms and cardiometabolic and related health could clarify risk factors and treatment targets. The objective of this study was to assess whether depression symptoms in midlife are associated with the subsequent onset of cardiometabolic health problems. Methods The study sample comprised 787 male twin veterans with polygenic risk score data who participated in the Harvard Twin Study of Substance Abuse ('baseline') and the longitudinal Vietnam Era Twin Study of Aging ('follow-up'). Depression symptoms were assessed at baseline [mean age 41.42 years (s.d. = 2.34)] using the Diagnostic Interview Schedule, Version III, Revised. The onset of eight cardiometabolic conditions (atrial fibrillation, diabetes, erectile dysfunction, hypercholesterolemia, hypertension, myocardial infarction, sleep apnea, and stroke) was assessed via self-reported doctor diagnosis at follow-up [mean age 67.59 years (s.d. = 2.41)]. Results Total depression symptoms were longitudinally associated with incident diabetes (OR 1.29, 95% CI 1.07-1.57), erectile dysfunction (OR 1.32, 95% CI 1.10-1.59), hypercholesterolemia (OR 1.26, 95% CI 1.04-1.53), and sleep apnea (OR 1.40, 95% CI 1.13-1.74) over 27 years after controlling for age, alcohol consumption, smoking, body mass index, C-reactive protein, and polygenic risk for specific health conditions. In sensitivity analyses that excluded somatic depression symptoms, only the association with sleep apnea remained significant (OR 1.32, 95% CI 1.09-1.60). Conclusions A history of depression symptoms by early midlife is associated with an elevated risk for subsequent development of several self-reported health conditions. When isolated, non-somatic depression symptoms are associated with incident self-reported sleep apnea. Depression symptom history may be a predictor or marker of cardiometabolic risk over decades.
#1Joanna Norton (French Institute of Health and Medical Research)H-Index: 15
#2M. Pastore (University of Montpellier)H-Index: 1
Last. Jorge Palacios ('KCL': King's College London)H-Index: 8
view all 7 authors...
BACKGROUND: Evidence suggests that somatic rather than cognitive depressive symptoms are risk factors for recurrent cardiac events in at-risk patients. However, this has never been explored using a time-dependent approach in a narrow time-frame, allowing a cardiac event-free time-window. METHODS: The analysis was performed on 595 participants [70.6% male, median age 72 (27-98)] drawn from the UPBEAT-UK heart disease patient cohort with 6-monthly follow-ups over 3 years. Depressive symptomatology...
3 CitationsSource
#1Selina Rajan (Lond: University of London)H-Index: 6
#2Martin McKee (Lond: University of London)H-Index: 152
view all 30 authors...
Importance Depression is associated with incidence of and premature death from cardiovascular disease (CVD) and cancer in high-income countries, but it is not known whether this is true in low- and middle-income countries and in urban areas, where most people with depression now live. Objective To identify any associations between depressive symptoms and incident CVD and all-cause mortality in countries at different levels of economic development and in urban and rural areas. Design, Setting, an...
13 CitationsSource
#1Jonathan R.I. Coleman (NIHR: National Institute for Health Research)H-Index: 28
#2Helena Gaspar (NIHR: National Institute for Health Research)H-Index: 30
view all 4 authors...
Abstract Background Mood disorders (including major depressive disorder and bipolar disorder) affect 10-20% of the population. They range from brief, mild episodes to severe, incapacitating conditions that markedly impact lives. Despite their diagnostic distinction, multiple approaches have shown considerable sharing of risk factors across the mood disorders. Methods To clarify their shared molecular genetic basis, and to highlight disorder-specific associations, we meta-analysed data from the l...
48 CitationsSource
#1Shahram Bahrami (University of Oslo)H-Index: 9
#2Nils Eiel Steen (University of Oslo)H-Index: 22
Last. Ole A. Andreassen (University of Oslo)H-Index: 123
view all 13 authors...
Importance People with major psychiatric disorders (MPDs) have a 10- to 20-year shorter life span than the rest of the population, and this difference is mainly due to comorbid cardiovascular diseases. Genome-wide association studies have identified common variants involved in schizophrenia (SCZ), bipolar disorder (BIP), and major depression (MD) and body mass index (BMI), a key cardiometabolic risk factor. However, genetic variants jointly influencing MPD and BMI remain largely unknown. Objecti...
24 CitationsSource
BACKGROUND: Persons with mental disorders are at a higher risk than the general population for the subsequent development of certain medical conditions. METHODS: We used a population-based cohort from Danish national registries that included data on more than 5.9 million persons born in Denmark from 1900 through 2015 and followed them from 2000 through 2016, for a total of 83.9 million person-years. We assessed 10 broad types of mental disorders and 9 broad categories of medical conditions (whic...
64 CitationsSource
#1Elizabeth Tarlov (UIC: University of Illinois at Chicago)H-Index: 12
#2Abigail Silva (LUC: Loyola University Chicago)H-Index: 7
Last. Shannon N. Zenk (UIC: University of Illinois at Chicago)H-Index: 37
view all 7 authors...
OBJECTIVE: Improving neighborhood walkability has been proposed as a policy intervention to reduce obesity. The objective of this study was to evaluate longitudinal relationships between neighborhood walkability and body weight among adults living in large urban areas. METHODS: In this retrospective longitudinal study of United States military veterans using Department of Veterans Affairs health care, Veterans Affairs clinical and administrative data (2007-2014) were linked to environmental meas...
4 CitationsSource
#1Jessica Tyrrell (RD&E: Royal Devon and Exeter Hospital)H-Index: 34
#2Anwar Mulugeta (UniSA: University of South Australia)H-Index: 8
Last. Elina Hyppönen (UniSA: University of South Australia)H-Index: 85
view all 19 authors...
BACKGROUND: Depression is more common in obese than non-obese individuals, especially in women, but the causal relationship between obesity and depression is complex and uncertain. Previous studies have used genetic variants associated with BMI to provide evidence that higher body mass index (BMI) causes depression, but have not tested whether this relationship is driven by the metabolic consequences of BMI nor for differences between men and women. METHODS: We performed a Mendelian randomizatio...
70 CitationsSource
#1Alicia R. Martin (Harvard University)H-Index: 29
#2Masahiro KanaiH-Index: 25
Last. Mark J. DalyH-Index: 213
view all 6 authors...
Polygenic risk scores (PRS) are poised to improve biomedical outcomes via precision medicine. However, the major ethical and scientific challenge surrounding clinical implementation of PRS is that those available today are several times more accurate in individuals of European ancestry than other ancestries. This disparity is an inescapable consequence of Eurocentric biases in genome-wide association studies, thus highlighting that—unlike clinical biomarkers and prescription drugs, which may ind...
563 CitationsSource
#1Mark W. Logue (BU: Boston University)H-Index: 33
#2Matthew S. Panizzon (UCSD: University of California, San Diego)H-Index: 35
Last. William S. Kremen (UCSD: University of California, San Diego)H-Index: 70
view all 14 authors...
Author(s): Logue, MW; Panizzon, MS; Elman, JA; Gillespie, NA; Hatton, SN; Gustavson, DE; Andreassen, OA; Dale, AM; Franz, CE; Lyons, MJ; Neale, MC; Reynolds, CA; Tu, X; Kremen, WS | Abstract: Early identification of younger, non-demented adults at elevated risk for Alzheimer's disease (AD) is crucial because the pathological process begins decades before dementia onset. Toward that end, we showed that an AD polygenic risk score (PRS) could identify mild cognitive impairment (MCI) in adults who w...
62 CitationsSource
#1Jonas Bovijn (University of Oxford)H-Index: 5
#2Leigh Jackson (University of Exeter)H-Index: 17
Last. Michael V. Holmes (NIHR: National Institute for Health Research)H-Index: 52
view all 22 authors...
Erectile dysfunction (ED) is a common condition affecting more than 20% of men over 60 years, yet little is known about its genetic architecture. We performed a genome-wide association study of ED in 6,175 case subjects among 223,805 European men and identified one locus at 6q16.3 (lead variant rs57989773, OR 1.20 per C-allele; p = 5.71 × 10 −14 ), located between MCHR2 and SIM1 . In silico analysis suggests SIM1 to confer ED risk through hypothalamic dysregulation. Mendelian randomization provi...
12 CitationsSource
Cited By1
#1Dani Beck (University of Oslo)H-Index: 5
#2de Lange AgH-Index: 1
Last. Lars T. WestlyeH-Index: 74
view all 20 authors...
There is an intimate body-brain connection in ageing, and obesity is a key risk factor for poor cardiometabolic health and neurodegenerative conditions. Although research has demonstrated deleterious effects of obesity on brain structure and function, the majority of studies have used conventional measures such as waist-to-hip ratio, waist circumference, and body mass index. While sensitive to gross features of body composition, such global anthropomorphic features fail to describe regional diff...
1 CitationsSource