Augmented Brain Delivery of Cinnarizine Through Nanostructured Lipid Carriers Loaded in situ Gel: in vitro and Pharmacokinetic Evaluation

The study envisaged the development of cinnarizine (CIN)-loaded nanostructured lipid carriers (NLCs) in situ gel, for intranasal delivery to the brain, for migraine treatment. The formulation was prepared and optimized by the solvent-evaporation method and central composite designs. The total lipid concentration (X1), surfactant concentration (X2), and sonication time (X3) were selected as critical material attributes, and the effects of...