Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia

Volume: 218, Issue: 2
Published: Jan 8, 2021
Abstract
Juvenile myelomonocytic leukemia (JMML) is a poor-prognosis childhood leukemia usually caused by RAS-pathway mutations. The cellular hierarchy in JMML is poorly characterized, including the identity of leukemia stem cells (LSCs). FACS and single-cell RNA sequencing reveal marked heterogeneity of JMML hematopoietic stem/progenitor cells (HSPCs), including an aberrant Lin-CD34+CD38-CD90+CD45RA+ population. Single-cell HSPC index-sorting and...
Paper Details
Title
Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia
Published Date
Jan 8, 2021
Volume
218
Issue
2
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