HER2 fluorescent in situ hybridization signal degradation: a 10-year retrospective study

Fluorescence in situ hybridization (FISH) analysis is recommended for invasive breast carcinomas with equivocal (2+) immunohistochemical expression of human epidermal growth factor receptor 2 (HER2). However, existing guidelines for the retention and storage requirements for HER2 FISH slides vary widely among countries and laboratories. To determine the degradation rate of HER2 FISH signals, and the optimal retention time and storage conditions...