Evaluation of a generalized knowledge-based planning performance for VMAT irradiation of breast and locoregional lymph nodes—Internal mammary and/or supraclavicular regions

Purpose To evaluate the performance of eleven Knowledge-Based (KB) models for planning optimization (RapidPlan tm (RP), Varian) of Volumetric Modulated Arc Therapy (VMAT) applied to whole breast comprehensive of nodal stations, internal mammary and/or supraclavicular regions. Methods and materials Six RP models have been generated and trained based on 120 VMAT plans data set with different criteria. Two extra-structures were delineated: a PTV...