Ergosterol limits osteoarthritis development and progression through activation of Nrf2 signaling

Osteoarthritis (OA) is a common joint disorder characterized by progressive articular cartilage degeneration and destruction and results in gradual disability among middle‑aged and elderly patients. Our previous study demonstrated that depletion of nuclear factor erythroid 2‑related factor 2 (Nrf2) exacerbated cartilage erosion in an OA model and that activation of the Nrf2 pathway could counter this process. As a downstream target of Nrf2, heme...